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Search Results for " vascular endothelium "

Targets Recommended: Integrin Complement System

15

抑制剂 & 化合物

3

天然产物

1

化合物库

16

重组蛋白

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Cat. No.	Product Name
L7500	凝血与抗凝化合物库		144 compounds
	144 个化合物的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

凝血与抗凝化合物库

Cat.No: L7500

Compounds: 144

Cat. No.	Product Name	Target	Signaling Pathways
T3638	Leukadherin-1	Integrin; Complement System	Cytoskeletal Signaling; Immunology/Inflammation
	Leukadherin-1 是 CD11b/CD18 的变构激活剂，可增加 CD11b/CD18 依赖性细胞对纤维蛋白原的粘附，减少白细胞运动和跨内皮迁移，具有抗炎作用。
T34541	SB-209670 SB 209670	Endothelin Receptor	GPCR/G Protein
	SB-209670是一种选择性内皮素受体拮抗剂，能够抑制大鼠血管内皮和血管平滑肌中ET(B)受体的活性。
T6264	Bosentan Actelion,波生坦,Ro 47-0203,Benzenesulfonamide	Endothelin Receptor	GPCR/G Protein
	Bosentan (Benzenesulfonamide) 是 endothelin-1 (ET)拮抗剂，在人的 SMC 细胞中，它能够作用于 ETA 受体(Ki:4.7 nM)和 ETB 受体(Ki:95 nM)。
T4567	Sulfaphenazole Plisulfan,Raziosulfa,Depocid,磺胺苯吡唑,Depotsulfonamide	P450; Antibacterial	Metabolism; Microbiology/Virology
	Sulfaphenazole (Plisulfan) 是一种 CYP2C9的特异性抑制剂，抑制 CYP2C9介导的亚油酸动脉粥样硬化和促炎症效应，增加 AP-1的氧化应激和激活。
T75154	ATU027
	ATU027, 一种可沉默血管内皮中PKN3表达的siRNA, 已在小鼠癌症模型中证明能有效抑制局部肿瘤侵袭及淋巴结和肺转移。
T70903	KRH102053
	KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 and monocarboxylate transporter 4. Consistent with these results, KRH102053 also inhibited the rates of HIF-related migration and invasion of HOS cells as well as the degree of tube formation in human umbilical vein endothelium cells.
T36150	14,15-EE-5(Z)-E
	Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a con...
T35464	(±)14(15)-EET-SI
	Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. The EETs are released in response to acetylcholine, bradykinin, arachidonic acid, or cyclic stretch. (±)14(15)-EET-SI is the methyl sulfonamide analog of 14(15)-EET. This substitution results in a metabolically more stable compound because it is not sensitive to β-oxidation or membrane esterification. (±)14(15)-EET-SI is equipotent to 14(15)-EET in vascular agonist act...
T76841	Enlimomab
	Enlimomab (BI-RR 0001) 是一种针对人 ICAM-1的小鼠 IgG2a 单抗，可抑制白细胞粘附到血管内皮，从而减少白细胞外渗漏和炎症性组织损伤。Enlimomab 具有抗炎作用，可用于中风研究。
T68511	KRH102140
	KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH102140 decreased the mRNA levels of HIF-regulated downstream target genes associated with angiogenesis and energy metabolism such as vascular endothelial growth factor, adrenomedullin, Glut1, aldolase A, enolase 1 and monocarboxylate transporter 4. KRH102140 also inhibited tube format...
T37234	(±)14(15)-EpETE
	EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoi...
T82683	Connexin mimetic peptide 40GAP27
	Connexin mimetic peptide 40GAP27 是一种生物活性肽，对应于主要的血管连接蛋白Cx40第二个细胞外环的GAP27结构域（40Gap27）。该化合物在研究氧化应激所致的损伤以及间隙连接通讯机制中有应用。40Gap27能够在给药后减少内皮依赖性的内膜下平滑肌的超极化现象。
T37238	(±)19(20)-EpDPA
	EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic...
T37235	(±)16(17)-EpDPA (±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA
	EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahex...
T82684	Connexin mimetic peptide 40,37GAP26
	Connexin mimetic peptide 40,37GAP26是一种生物活性肽，对应Cx37和Cx40主要血管连接蛋白的胞外环GAP26结构域，命名基于Cx同源性为37,40Gap26。本化合物主要用于研究间隙连接对环吡嗪酸(CPA)通过啮齿动物髂动脉壁导致的内皮超极化扩散的影响。Cx37和Cx40形成的间隙连接斑块在内皮细胞中高度丰富，而Connexin mimetic peptide 40,37GAP26能抑制内膜下超极化。

化合物

Cat.No: T3638

Target: Integrin, Complement System

Cat.No: T34541

Synonym: SB 209670

Target: Endothelin Receptor

Cat.No: T6264

Synonym: Actelion,波生坦,Ro 47-0203,Benzenesulfonamide

Target: Endothelin Receptor

Cat.No: T4567

Synonym: Plisulfan,Raziosulfa,Depocid,磺胺苯吡唑,Depotsulfonamide

Target: P450, Antibacterial

Cat.No: T75154

Cat.No: T70903

14,15-EE-5(Z)-E

Cat.No: T36150

(±)14(15)-EET-SI

Cat.No: T35464

Cat.No: T76841

Cat.No: T68511

(±)14(15)-EpETE

Cat.No: T37234

Connexin mimetic peptide 40GAP27

Cat.No: T82683

(±)19(20)-EpDPA

Cat.No: T37238

(±)16(17)-EpDPA

Cat.No: T37235

Synonym: (±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA

Connexin mimetic peptide 40,37GAP26

Cat.No: T82684

Cat. No.	Product Name	Target	Signaling Pathways
TN1567	Delphinidin chloride	Estrogen Receptor/ERR; VEGFR	Angiogenesis; Endocrinology/Hormones; Tyrosine Kinase/Adaptors
	Delphinidin chloride 是一种花青素，是一种可从浆果和红酒中分离得到的天然植物色素，是某些花青素的前体。Delphinidin chloride 诱导血管内皮释放一氧化氮，引起血管松弛。在1 ~ 40 μM 剂量下，对上皮生长因子受体的信号传导和雌激素受体α的表达有抑制作用，与细胞凋亡和自噬有关。Delphinidin chloride 能调节 JAK/STAT3 和 MAPKinase 信号传导。Delphinidin 还能抑制 p300/CBP 的组蛋白乙酰转移酶活性(IC50 在约为30 μM)
T3794	Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖	Influenza Virus	Microbiology/Virology
	1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中，具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
T37974	(S)-Coriolic acid 13(S)-HODE	Lipoxygenase; Mitochondrial Metabolism; PPAR	DNA Damage/DNA Repair; Metabolism
	(S)-Coriolic acid (13(S)-HODE) 是一种重要的细胞内信号剂，是亚油酸与植物和哺乳动物脂氧合酶反应生成的，在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 在 1 μM 左右时，它能抑制肿瘤细胞与血管内皮的粘附，能下调 IRGpIIb/IIIa 受体的表达。(S)-Coriolic acid 是15-脂氧合酶 (15-LOX) 代谢产物，常作为内源性配体激活 PPARγ。(S)-Coriolic acid 诱导线粒体功能障碍和气道上皮损伤。

天然产物

Delphinidin chloride

Cat.No: TN1567

Target: Estrogen Receptor/ERR, VEGFR

Pentagalloylglucose

Cat.No: T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Target: Influenza Virus

(S)-Coriolic acid

Cat.No: T37974

Synonym: 13(S)-HODE

Target: Lipoxygenase, Mitochondrial Metabolism, PPAR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03305	VE-Cadherin Protein, Rat, Recombinant (His) cadherin 5, type 2 (vascular endothelium)	Rat	HEK293 Cells
	VE-Cadherin Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 65.1 kDa and the accession number is A6JXX3.
TMPY-01677	VE-Cadherin Protein, Human, Recombinant (His & hFc) cadherin 5, type 2 (vascular endothelium),...	Human	HEK293 Cells
	VE-Cadherin Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 92 kDa and the accession number is P33151-1.
TMPY-01237	VE-Cadherin Protein, Mouse, Recombinant (His) VECD,VE-Cad,Cd144,7B4,Vec,VEcad,cadherin 5, type 2 (vasc...	Mouse	HEK293 Cells
	VE-Cadherin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 63.5 kDa and the accession number is P55284.
TMPK-00359	Endoglin/CD105 Protein, Human, Recombinant (His & Avi) CD105,ORW,ORW1,ENG,END,Endoglin,HHT1	Human	HEK293 Cells
	Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response...
TMPK-00350	E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated CD62E,ELAM,SELE,selectin E,LECAM2,ESEL,RP1-117P20.2,ELAM1,E-...	Human	HEK293 Cells
	E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated is expre...
TMPK-00349	E-Selectin/CD62E Protein, Human, Recombinant (His & Avi) ESEL,RP1-117P20.2,CD62E,ELAM,ELAM1,selectin E,E-Selectin,LEC...	Human	HEK293 Cells
	E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. E-Selectin/CD62E Protein, Human, Recombinant (His & Avi) is expressed in HEK293...
TMPK-00487	E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His) selectin E,ELAM,ESEL,SELE,E-Selectin,LECAM2,CD62E,ELAM1	Cynomolgus	HEK293 Cells
	E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His) is expressed...
TMPJ-00257	PSGL-1/CD162 Protein, Human, Recombinant (hFc) Selectin P ligand,P-selectin glycoprotein ligand 1,SELPLG,CD...	Human	HEK293 Cells
	PSGL-1 (CD162), is a mucintype glycoprotein that plays a key role in leukocyte adhesion. Human PSGL-1 cDNA encodes 412 amino acids (aa). It expressed on neutrophils, monocytes and most lymphocytes. The mature PSGL-1 (aa 42-412) is expressed as a disulfide-linked homodimer that signals intracellularly and promotes integrin activation. PSGL-1 is found on virtually all leukocytes, dendritic cells, platelets, and some endothelial cells. It is primarily responsible for early events in extravasation, ...
TMPJ-00361	Endoglin Protein, Human, Recombinant (Trx & His) CD105,END,Endoglin,ENG	Human	E. coli
	Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Homodimer forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It may have an important role in the binding of endothelial cells to integrins an...
TMPJ-00379	AOC3 Protein, Human, Recombinant (hFc) SSAO,AOC3,Membrane primary amine oxidase,Copper amine oxidas...	Human	HEK293 Cells
	Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycoprotein that has a distal adhesion domain and an enzymatically active amine oxidase site outside of the membrane, VAP-1 has adhesive properties, functional monoamine oxidase activity, and possibly plays a role in glucose handling, leukocyte trafficking, and migration during inflam...
TMPJ-00921	COL8A1 Protein, Human, Recombinant (His) Vastatin,Endothelial Collagen,Collagen Alpha-1(VIII) Chain,C...	Human	HEK293 Cells
	Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endothelium. COL8A1 forms homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrhedron stabilized by central interacting C-terminal NC1 trimers. COL8A1 contains one C1q domain and is primarily expressed in the subendothelium o...
TMPJ-00264	LAMP1 Protein, Human, Recombinant (hFc) LAMP-1,CD107a,Lysosome-Associated Membrane Glycoprotein 1,LA...	Human	HEK293 Cells
	Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells.It shuttles between lysosomes, endosomes, and the plasma membrane. LAMP1 functions to present carbohydrate ligands to selectins and it has also been implicated in tumor cell metastasis. It has been proposed LAMP1 can be used as a therapeutic agent for certain cancers, as well as a marker for lysosomal sto...
TMPY-00410	EPHX2 Protein, Human, Recombinant (His) SEH,CEH,epoxide hydrolase 2, cytoplasmic	Human	Baculovirus Insect Cells
	Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene had been implicated in susceptibility to cardiovascular disease, including stroke. The human EPHX2 mutations may in part explain the genetic variability in sensitivity to ischemic brain injury and stroke outcome. Epoxide hydrolase is involved in metabolism of vas...
TMPY-01052	R-Cadherin/CDH4 Protein, Human, Recombinant (His) R-CAD,cadherin 4, type 1, R-cadherin (retinal),RCAD,CAD4	Human	HEK293 Cells
	The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion events, and can be divided into at least four subfamilies based on the extracellular (EC) regions and cytoplasmic domains, that is: classical cadherins, desmosomal cadherins, protocadherins, and cadherin-like molecules. Human cadherin 4, type 1, R-cadherin (retinal), also known as CDH4, CAD4 and RCAD, is a classical cadherin from the cadherin superfamily. It is a calcium-de...
TMPJ-00831	CCL3 Protein, Mouse, Recombinant (His) LD78 α,MIP-1 α,MIP1-a,MIP-1 alpha,LD78 alpha,chemokine (C-C ...	Mouse	E. coli
	C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, smooth muscle cells, and epithelial cells. Mature mouse CCL3 shares 73%, 91%, and 82% amino acid sequence identity with human, rat, and cotton rat CCL3, respectively. CCL3 exerts its biological functions through interactions with CCR1, CCR3, and CCR5. It is cleared from the extra...
TMPY-01345	ACBD6 Protein, Human, Recombinant (His) acyl-CoA binding domain containing 6	Human	Baculovirus Insect Cells
	Human acyl-coenzyme A binding domain-containing member 6 (ACBD6) is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus. In mammals, there are six members of the acyl-CoA binding domain-containing (ACBD) family, and their annotation is not uniform. All six ACBD proteins contain an ACB domain at the N terminus, but they do not share significant homology at the C-terminal region. ACBD6 is a 32 kDa protein that is predicted by sequenc...

重组蛋白

VE-Cadherin Protein, Rat, Recombinant (His)

Cat.No: TMPY-03305

Species: Rat

Expression System: HEK293 Cells

VE-Cadherin Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-01677

Species: Human

Expression System: HEK293 Cells

VE-Cadherin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01237

Species: Mouse

Expression System: HEK293 Cells

Endoglin/CD105 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00359

Species: Human

Expression System: HEK293 Cells

E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00350

Species: Human

Expression System: HEK293 Cells

E-Selectin/CD62E Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00349

Species: Human

Expression System: HEK293 Cells

E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His)

Cat.No: TMPK-00487

Species: Cynomolgus

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00257

Species: Human

Expression System: HEK293 Cells

Endoglin Protein, Human, Recombinant (Trx & His)

Cat.No: TMPJ-00361

Species: Human

Expression System: E. coli

AOC3 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00379

Species: Human

Expression System: HEK293 Cells

COL8A1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00921

Species: Human

Expression System: HEK293 Cells

LAMP1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00264

Species: Human

Expression System: HEK293 Cells

EPHX2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00410

Species: Human

Expression System: Baculovirus Insect Cells

R-Cadherin/CDH4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01052

Species: Human

Expression System: HEK293 Cells

CCL3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00831

Species: Mouse

Expression System: E. coli

ACBD6 Protein, Human, Recombinant (His)

Cat.No: TMPY-01345

Species: Human

Expression System: Baculovirus Insect Cells

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